Ruiqing Hou¹, Frank Feyerabend¹, Regine Willumeit Romer¹; ¹Helmholtz Center Geesthacht

To understand the magnesium (Mg) degradation mechanism in vivo, a variety of in vitro investigations were conducted. However, there is still a discrepancy of in vitro results with in vivo observations. Herein, the combined effect of proteins and medium flow condition on magnesium degradation was studied. Bovine serum albumin (BSA) and fetal bovine serum (FBS) were applied as the commonly used protein components for in vitro tests. Static condition, a medium changing method (semi-static) and continuous medium flow (dynamic) were used to present different conditions. The results showed the largest degradation inhibition efficiency of BSA and FBS to Mg degradation under static condition, while the efficiency largely decreased when the semi-static or dynamic condition were used, especially for BSA. The possible explanations are related to the composition of degradation products and the integrity of degradation layer. These results emphasis the importance of considering effects from different factors during magnesium degradation.